Journal article
Ryan T Woodall, Stephanie L. Barnes, D. Hormuth, A. Sorace, C. Quarles, T. Yankeelov
Magnetic Resonance in Medicine, 2018
Magnetic Resonance in Medicine, 2018
Semantic Scholar
DOI
PubMed
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APA
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Woodall, R. T., Barnes, S. L., Hormuth, D., Sorace, A., Quarles, C., & Yankeelov, T. (2018). The effects of intravoxel contrast agent diffusion on the analysis of DCE‐MRI data in realistic tissue domains. Magnetic Resonance in Medicine.
Chicago/Turabian
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Woodall, Ryan T, Stephanie L. Barnes, D. Hormuth, A. Sorace, C. Quarles, and T. Yankeelov. “The Effects of Intravoxel Contrast Agent Diffusion on the Analysis of DCE‐MRI Data in Realistic Tissue Domains.” Magnetic Resonance in Medicine (2018).
MLA
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Woodall, Ryan T., et al. “The Effects of Intravoxel Contrast Agent Diffusion on the Analysis of DCE‐MRI Data in Realistic Tissue Domains.” Magnetic Resonance in Medicine, 2018.
BibTeX Click to copy
@article{ryan2018a,
title = {The effects of intravoxel contrast agent diffusion on the analysis of DCE‐MRI data in realistic tissue domains},
year = {2018},
journal = {Magnetic Resonance in Medicine},
author = {Woodall, Ryan T and Barnes, Stephanie L. and Hormuth, D. and Sorace, A. and Quarles, C. and Yankeelov, T.}
}
Abstract
Quantitative evaluation of dynamic contrast enhanced MRI (DCE‐MRI) allows for estimating perfusion, vessel permeability, and tissue volume fractions by fitting signal intensity curves to pharmacokinetic models. These compart mental models assume rapid equilibration of contrast agent within each voxel. However, there is increasing evidence that this assumption is violated for small molecular weight gadolinium chelates. To evaluate the error introduced by this invalid assumption, we simulated DCE‐MRI experiments with volume fractions computed from entire histological tumor cross‐sections obtained from murine studies.
